Introduction to HIV and cancerSimon CollinsHIV i-Base.ppt

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1、Introduction to HIV and cancerSimon Collins HIV i-Base,Introduction, Area of expert care referrals and networks BHIVA guidelines Personal aims for the day? HIV and cancer general points HIV and cancer scientific concepts Activist agenda? Personal comments,HIV and cancer, We are lucky to be ageing Bu

2、t cancer is often an age-related disease - highest risk comes with age 75% of people have a lifetime cancer risk - is this a natural ageing process? Over 200 cancers each very specific Many are treatable, with high (90%) remission rates if detected early (screening / surveillance / self monitoring e

3、tc) Some are not - make the most of life.,HIV and cancer, Expert care essential Cancer treatment is very different to ART - less data for modified combinations, best guess approach. Extended timelines for progression, treatment and treatment outcomes. Risks are multi-factorial and often related to m

4、odifiable lifestyle factors. Personal perspective - prioritise your health.,HIV and cancer: scientific issues, Difficulty of knowing any independent risk from HIV impact of ART/non- ART and viral suppression. Difficultly of not having an appropriate matched control group. Higher rates reported for s

5、ome and at earlier age but adjusting for cohort ages of reduced the differences in both incidence and age at diagnosis.,HIV and cancer: scientific issues, Relative vs absolute risks Issues of screen and risk/benefit balance with screening. Common sense approach for broad screening programmes is not

6、always supported by evidence. Difficulty of separating earlier diagnosis and mortality. Activist role/agenda,Thanks,Further info Macmillan http:/www.macmillan.org.uk BHIVA malignancy guidelines http:/www.bhiva.org/Guidelines.aspx UK-CAB reading for April 2013 meeting, including: Do cancer patients with HIV die sooner? Mark Bower. http:/www.bhiva.org/121004MarkBower.aspx,