DIN EN 16343-2013 Cosmetics - Analysis of cosmetic products - Determination of 3-iodo-2-propynyl butylcarbamate (IPBC) in cosmetic preparations LC-MS methods German version EN 1634.pdf
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1、August 2013 Translation by DIN-Sprachendienst.English price group 8No part of this translation may be reproduced without prior permission ofDIN Deutsches Institut fr Normung e. V., Berlin. Beuth Verlag GmbH, 10772 Berlin, Germany,has the exclusive right of sale for German Standards (DIN-Normen).ICS
2、71.100.70!%fA“2046730www.din.deDDIN EN 16343Cosmetics Analysis of cosmetic products Determination of 3-iodo-2-propynyl butylcarbamate (IPBC) in cosmeticpreparations, LC-MS methods;English version EN 16343:2013,English translation of DIN EN 16343:2013-08Kosmetische Mittel Untersuchung von kosmetische
3、n Mitteln Bestimmung von 3-Iod-2-propinylbutylcarbamat (IPBC) in kosmetischen Mitteln,LC-MS-Verfahren;Englische Fassung EN 16343:2013,Englische bersetzung von DIN EN 16343:2013-08Cosmtiques Analyse des produits cosmtiques Dtermination quantitative du carbamate 3-iodo-2-propynylbutyle (IPBC),mthodes
4、CL-SM;Version anglaise EN 16343:2013,Traduction anglaise de DIN EN 16343:2013-08www.beuth.deIn case of doubt, the German-language original shall be considered authoritative.Document comprises 11 pages 07.13 DIN EN 16343:2013-08 2 A comma is used as the decimal marker. National foreword This document
5、 (EN 16343:2013) has been prepared by Technical Committee CEN/TC 392 “Cosmetics” (Secretariat: AFNOR, France). The responsible German body involved in its preparation was the Normenausschuss Lebensmittel und landwirtschaftliche Produkte (Food and Agricultural Products Standards Committee), Working C
6、ommittee NA 057-07-01 AA Kosmetische Mittel. EUROPEAN STANDARD NORME EUROPENNE EUROPISCHE NORM EN 16343 May 2013 ICS 71.100.70 English Version Cosmetics - Analysis of cosmetic products - Determination of 3-iodo-2-propynyl butylcarbamate (IPBC) in cosmetic preparations, LC-MS methods Cosmtiques - Ana
7、lyse des produits cosmtiques - Dtermination quantitative du carbamate 3-iodo-2-propynylbutyle (IPBC), mthodes CL-SM Kosmetische Mittel - Untersuchung von kosmetischen Mitteln - Bestimmung von 3-Iod-2-propinylbutylcarbamat (IPBC) in kosmetischen Mitteln, LC-MS-Verfahren This European Standard was app
8、roved by CEN on 25 April 2013. CEN members are bound to comply with the CEN/CENELEC Internal Regulations which stipulate the conditions for giving this European Standard the status of a national standard without any alteration. Up-to-date lists and bibliographical references concerning such national
9、 standards may be obtained on application to the CEN-CENELEC Management Centre or to any CEN member. This European Standard exists in three official versions (English, French, German). A version in any other language made by translation under the responsibility of a CEN member into its own language
10、and notified to the CEN-CENELEC Management Centre has the same status as the official versions. CEN members are the national standards bodies of Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, Former Yugoslav Republic of Macedonia, France, Germany, Greece, Hun
11、gary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and United Kingdom. EUROPEAN COMMITTEE FOR STANDARDIZATION COMIT EUROPEN DE NORMALISATION EUROPISCHES KOMITEE FR NORMUNG Managem
12、ent Centre: Avenue Marnix 17, B-1000 Brussels 2013 CEN All rights of exploitation in any form and by any means reserved worldwide for CEN national Members. Ref. No. EN 16343:2013: EEN 16343:2013 (E) 2 Contents Page Foreword . 3 1 Scope 4 2 Principle 4 3 Reagents . 4 4 Apparatus and equipment . 5 5 P
13、rocedure . 5 6 Evaluation . 7 7 Test report 7 Annex A (informative) Results of the inter-laboratory test . 8 Bibliography 9 DIN EN 16343:2013-08 EN 16343:2013 (E) 3 Foreword This document (EN 16343:2013) has been prepared by Technical Committee CEN/TC 392 “Cosmetics”, the secretariat of which is hel
14、d by AFNOR. This European Standard shall be given the status of a national standard, either by publication of an identical text or by endorsement, at the latest by November 2013, and conflicting national standards shall be withdrawn at the latest by November 2013. Attention is drawn to the possibili
15、ty that some of the elements of this document may be the subject of patent rights. CEN and/or CENELEC shall not be held responsible for identifying any or all such patent rights. According to the CEN-CENELEC Internal Regulations, the national standards organizations of the following countries are bo
16、und to implement this European Standard: Austria, Belgium, Bulgaria, Croatia, Cyprus, Czech Republic, Denmark, Estonia, Finland, Former Yugoslav Republic of Macedonia, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portug
17、al, Romania, Slovakia, Slovenia, Spain, Sweden, Switzerland, Turkey and the United Kingdom. DIN EN 16343:2013-08 EN 16343:2013 (E) 4 1 Scope This European Standard specifies a method for the quantitative determination of 3-iodo-2-propynyl butylcarbamate (IPBC) in the concentration range from 0,005 g
18、/100 g to 0,1 g/100 g - Annex V No. 56 in Regulation (EC) No 1223/2009 on cosmetic products. 2 Principle IPBC is extracted from the cosmetic preparation using methanol. IPBC present in the sample extract is separated using reverse phase HPLC with mass specific detection (LC-MS or LC-MS/MS). Quantita
19、tive determination of IPBC is made using the external standard method of calibration or standard addition. 3 Reagents 3.1 General If not otherwise specified, analytical-grade chemicals shall be used; water shall be distilled or of a suitable purity. “Solution” shall be understood as an aqueous solut
20、ion unless otherwise specified. 3.2 Iodopropynyl butylcarbamat, CAS number: 55406-53-6 (Supplier : Sigma-Aldrich1)(521949), Dr. Ehrenstorfer GmbH1)(C 14335000). 3.3 Methanol, HPLC grade, CAS number: 67-56-1. 3.4 Formic acid, CAS number: 64-18-6. 3.5 Tetrahydrofuran (THF), CAS number: 109-99-9. 3.6 P
21、ropan-2-ol, CAS number: 67-63-0. 3.7 Eluents 3.7.1 Eluent A, 1 ml of formic acid (3.4) is mixed with 1 000 ml of water. 3.7.2 Eluent B, Methanol (3.3). 3.8 IPBC stock solution, = 1 mg/ml. Weigh approximately 0,05 g of IPBC (3.2) into a 50-ml-volumetric flask. Firstly, dissolve in a small amount of m
22、ethanol (3.3) and then fill up to the calibration mark with methanol. This solution has a shelf life of 8 weeks if it is stored in a refrigerator. 3.9 Calibration solutions (standard solutions) 5,0 ml of the stock solution (3.8) is transferred into a 50-ml-volumetric flask and filled to the calibrat
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