GOST 32296-2013 Testing of chemicals of health hazard Acute oral toxicity fixed dose procedure《危害健康的化学品试验 急性口服毒性固定计量法》.pdf

《GOST 32296-2013 Testing of chemicals of health hazard Acute oral toxicity fixed dose procedure《危害健康的化学品试验 急性口服毒性固定计量法》.pdf》由会员分享，可在线阅读，更多相关《GOST 32296-2013 Testing of chemicals of health hazard Acute oral toxicity fixed dose procedure《危害健康的化学品试验 急性口服毒性固定计量法》.pdf（16页珍藏版）》请在麦多课文档分享上搜索。

1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) 32296 2013 (OECD, Test No420:2001, IDT) 322962013 II , 1.092 . 1.22009 . , . , , , 1 ( ), - , , ( ) 2 3 , ( 14 2013 . 442013) : ( 3166) 004 97 ( 3166) 004 97 AM BY KG MD RU TJ - 4 OECD Test 420 Acute Oral Toxicity Fixed

2、Dose Procedure ( 420 - ). (en). (IDT) 5 22 2013 . 795- 322962013 1 2014 . 6 , . () . , , 2014 , 322962013 III 2. . in vivo 3, 4 , , , , , . (Guidance Document on Acute Oral Toxicity Testing) 8. , , , , . , , . , , , , . , 3. 322962013 1 esting of chemicals of health hazard Acute Oral Toxicity Fixed

3、Dose Procedure 20140801 1 . . . ; - ; in vivo in vitro, . , . 2 : 2.1 (Moribund status): , . 2.2 (Dose): . /. 2.3 (Delayed death): , 48 , , 14 . 2.4 (Acute oral toxicity): , 24 . 2.5 (Evident toxicity): , , 3. 2.6 () (Limit dose): (2000 5000 /). 2.7 (Predictable death): , , (, ). 2.8 (Impending deat

4、h): , . , , . . 2.9 (Globally Harmonised Classification System for Chemical Substances and Mixtures GHS): . (OECD, ), (- ) (ILO, ). (IOMC). 2.10 DL50/LD50( , ): , 50 % . , DL50/LD50 /. 322962013 2 3 , , 5, 50, 300 2000 / ( 5000 /). , , . , , , . , , . , , , . 4 4.1 4.1.1 , . , 8, 11. , , . . . . 8 1

5、2 , 20 % . 4.1.2 (22 3) . 30% 70 %, ; 50 % 60 %. 12 , 12 . . , . 4.1.3 , , . 4.2 4.2.1 , . , , . . 1 /100 : , 2 /100 . , . / , , , / ( ). (), , . . 4.2.2 : . , , 24 . (. 322962013 3 , ; - , ). , . , . , . 4.3 . . , ( ). (5, 50, 300 2000 /) , in vivo in vitro. 300 /. , , 24 . , , 14 . , , 5000 / ( 4.6). , , 5 ( 2000 5000 /) , . , (5 /) , 1 ( ).