ASTM E2169-2001(2007) Standard Practice for Selecting Antimicrobial Pesticides for Use in Water-Miscible Metalworking Fluids《可混合水的金属加工液中使用的抗菌杀虫剂选择的标准实施规范》.pdf
《ASTM E2169-2001(2007) Standard Practice for Selecting Antimicrobial Pesticides for Use in Water-Miscible Metalworking Fluids《可混合水的金属加工液中使用的抗菌杀虫剂选择的标准实施规范》.pdf》由会员分享,可在线阅读,更多相关《ASTM E2169-2001(2007) Standard Practice for Selecting Antimicrobial Pesticides for Use in Water-Miscible Metalworking Fluids《可混合水的金属加工液中使用的抗菌杀虫剂选择的标准实施规范》.pdf(7页珍藏版)》请在麦多课文档分享上搜索。
1、Designation: E 2169 01 (Reapproved 2007)An American National StandardStandard Practice forSelecting Antimicrobial Pesticides for Use in Water-MiscibleMetalworking Fluids1This standard is issued under the fixed designation E 2169; the number immediately following the designation indicates the year of
2、original adoption or, in the case of revision, the year of last revision. A number in parentheses indicates the year of last reapproval. Asuperscript epsilon (e) indicates an editorial change since the last revision or reapproval.1. Scope1.1 This practice provides recommendations for selectingantimi
3、crobial pesticides (microbicides) for use in water-miscible metalworking fluids (MWF). It presents informationregarding regulatory requirements, as well as technical factorsincluding target microbes, efficacy and chemical compatibility.1.2 This guide is not an encyclopedic compilation of all theconc
4、epts and terminology uses by chemists, microbiologists,toxicologists, formulators, plant engineers and regulatory af-fairs specialists involved in antimicrobial pesticide selectionand application. Instead, it provides a general understanding ofthe selection process and its supporting considerations.
5、1.3 The values in SI units are to be regarded as the standard.1.4 This standard does not purport to address all of thesafety concerns, if any, associated with its use. It is theresponsibility of the user of this standard to establish appro-priate safety and health practices and determine the applica
6、-bility of regulatory limitations prior to use.2. Referenced Documents2.1 ASTM Standards:2D 1067 Test Methods for Acidity or Alkalinity of WaterD 1293 Test Methods for pH of WaterD 3519 Test Method for Foam in Aqueous Media (BlenderTest)D 3946 Test Method for Evaluating the Bacteria Resistanceof Wat
7、er-Dilutable Metalworking Fluids3D 4478 Test Methods for Oxygen Uptake3D 5465 Practice for Determining Microbial Colony Countsfrom Waters Analyzed by Plating MethodsE 686 Method for Evaluation of Antimicrobial Agents inAqueous Metal Working Fluids3E 1302 Guide for Acute Animal Toxicity Testing of Wa
8、ter-Miscible Metalworking FluidsE 1326 Guide for Evaluating Nonconventional Microbio-logical Tests Used for Enumerating BacteriaE 1497 Practice for Selection and Safe Use of Water-Miscible and Straight Oil Metal Removal FluidsE 2144 Practice for Personal Sampling and Analysis ofEndotoxin in Metalwor
9、king Fluid Aerosols in WorkplaceAtmospheres2.2 Government Standards:29 CFR 1910 Occupational Safety and Health Standards440 CFR 152 Pesticide Registration and Classification Pro-cedures440 CFR 158 Pesticide Programs Data Requirements forRegistration449 CFR 100-180 Research and Special Programs Admin
10、is-tration, Department of Transportation4PR Notice 2000-1 Applicability of the Treated ArticlesExemption to Antimicrobial PesticidesDirective 98/8/EC of the European Parliament and of theCouncil of 16 February 1998 concerning the placing ofbiocidal products on the market3. Terminology3.1 active ingr
11、edient (a.i.), nthe chemical component orcomponents of an antimicrobial pesticide that provides itsmicrobicidal performance.3.2 activity spectrum, nvariety or range of microbesagainst which an antimicrobial pesticide is effective.3.3 antimicrobial pesticide, nchemical additive, regis-tered under 40
12、CFR 152, for use to inhibit growth, proliferationor both of microorganisms.3.3.1 DiscussionAntimicrobial pesticides are registeredfor one or more end-use applications, or sites, for use within anapproved dose range.3.4 bactericide, nantimicrobial pesticide specifically orprimarily effective against
13、bacteria.3.5 biocide, nany chemical intended for use to kill orinhibit organisms.1This practice is under the jurisdiction of ASTM Committee E34 on Occupa-tional Health and Safety and is the direct responsibility of Subcommittee E34.50 onHealth and Safety Standards for Metal Working Fluids.Current ed
14、ition approved April 1, 2007. Published June 2007. Originallyapproved in 2001. Last previous edition approved in 2001 as E 2169 - 01.2For referenced ASTM standards, visit the ASTM website, www.astm.org, orcontact ASTM Customer Service at serviceastm.org. For Annual Book of ASTMStandards volume infor
15、mation, refer to the standards Document Summary page onthe ASTM website.3Withdrawn.4Code of Federal regulations available form United States Government PrintingOffice, Washington, DC.1Copyright ASTM International, 100 Barr Harbor Drive, PO Box C700, West Conshohocken, PA 19428-2959, United States.3.
16、5.1 DiscussionBiocide is a term commonly used syn-onymously with the preferred antimicrobial pesticide or mi-crobicide.3.6 bioburden, nthe level of microbial contamination(biomass) in a system.3.6.1 DiscussionTypically bioburden is defined in termsof either biomass or numbers of cells per unit volum
17、e or massor surface area material tested (g biomass/mL sample; gbiomass/g sample; cell/mL sample, colony forming units(CFU)/mL, and so forth).3.7 biodeterioration, nthe loss of commercial value, per-formance characteristics or both of a product (metalworkingfluid) or material (coolant system or fini
18、shed parts) throughbiological processes.3.8 biofilm, na film or layer composed of microorgan-isms, biopolymers, water, and entrained organic and inorganicdebris that forms as a result of microbial growth, proliferation,and excretion of polymeric substances at phase interfaces(liquid-liquid, liquid-s
19、olid, liquid-gas, and so forth). (synonym:skinnogen layer).3.9 bioresistant, adjability to withstand biological attack.3.9.1 DiscussionBioresistant, or recalcitrant, chemicalsare not readily metabolized by microorganisms.3.10 biostatic, adjable to prevent existing microbial con-taminants from growin
20、g or proliferating, but unable to killthem.3.10.1 DiscussionBiostatic additives may be registeredantimicrobial pesticides or unregistered chemicals with otherperformance properties. The difference between biocidal andbiostatic performance may be attributed to dose, chemistry orboth.3.11 contaminatio
21、n control, nmaintenance of bioburdenat an operationally defined level, at or below which thebioburden does not affect the fluid or system adversely.3.12 demand, nthe sum of all factors that contribute todecreasing the effective concentration of antimicrobial pesti-cide.3.12.1 DiscussionProcesses con
22、tributing to demand in-clude, but are not limited to, reaction with microbes, reactionswith other chemicals in the fluid, adsorption onto surfaces,absorption into materials and temperature.3.13 dose, nconcentration of antimicrobial pesticideadded to treated solution.3.13.1 DiscussionDose is generall
23、y expressed as eitherppm active ingredient (a.i.) or ppm as supplied (a.s.).3.14 fungicide, nantimicrobial pesticide specifically orprimarily effective against fungi.3.15 lethal dose, nconcentration at which treatment killsat least one of test subjects.3.15.1 DiscussionThe LD50is the term used in to
24、xicologydefining the dose that kills fifty-percent of the test population.3.16 half-life (T12 ), ntime required for concentration of amicrobicide to diminish to one-half its initial concentration.3.17 microbicide, nsynonymous with antimicrobial pesti-cide.3.18 minimum inhibitory concentration (MIC),
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