大学四级-1108及答案解析.doc
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1、大学四级-1108 及答案解析(总分:712.00,做题时间:90 分钟)一、Part Writing(总题数:1,分数:106.00)1.据称,在你所在的社区将建立一个大型的购物中心;2发表你的意见并说出支持或反对的理由。A Shopping Mall in the Neighborhood(分数:106.00)_二、Part Reading Compr(总题数:1,分数:70.00)Genetic TestingGenetic testing is transforming medicine and the way families think about their health. As
2、 science uncovers the complicated secrets of DNA, we face difficult choices and new challenges.About Genetic testingThe year was 1895 and Pauline Gross, a young actress, was scared. Gross knew nothing about the human-genome (基因组,染色体组) projectsuch medical triumphs, but she did know about a nasty dise
3、ase called cancer, and it was running through her family. “Im healthy now,“ she often told Dr. Aldred Warthin from at the University of Michigan, “but I fully expect to die an early death.“At the time, Grosss prediction was based solely on observation: family members had died of cancer; she would, t
4、oo. Today, more than 100 years later, Grosss relatives have a much more clinical option: genetic testing. With a simple blood test; they can peer into their own DNA, learningwhile still perfectly healthywhether they carry an inheritable gene mutation (突变) that has dogged their family for decades and
5、 puts them at serious risk.Take the TestingTesting is a kind of the genomic revolution. A major goal is to create new sophisticated therapies that home in on a diseases biological source, then fix the problem. Already, genes are helping to predict a patients response to existing medications. A prime
6、 example, taken by Dr, Wylie Burke of the University of Washington, is a variant of a gene called TPMT, which can lead to life-threatening reactions to certain doses of chemotherapy (化学疗法). A genetic test can guide safe and appropriate treatment. Two genes have been identified that influence a perso
7、ns response to the anti-blood-clotting drug. And scientists are uncovering genetic differences in the way people respond to other widely used medications, like antidepressants (抗抑郁药).Knowing a patients genotype, or genetic profile, may also help researchers uncover new preventive therapies for stick
8、y diseases. At Johns Hopkins University School of Medicine. Dr. Christopher Ross has tested several compounds shown to slow the progression of Huntingtons in mice. Now he wants to test them in people who are positive for the Huntingtons mutation but have not developed symptomsa novel approach to cli
9、nical drug trials, which almost always involve sick people seeking cures. “Were using genetics to move from treating the disease after it happens,“ he says, “to preventing the worst symptoms of the disease before it happens.“Its not just their own health that people care about. There is also the des
10、ire to get rid of disease from the family tree. Therefore, the future is what drives many adults to the clinic. The gene tests currently offered for certain diseases, like breast cancer, affect only a small percentage of total cases. Inherited mutations contribute to just 5 to 10 percent of all brea
11、st cancers. But the impact on a single life can be huge. The key: being able to do something to ward off disease. “Genetic testing offers us profound insight,“ says Dr. Stephen Gruber, of the University of Michigan. “But it has to be balanced with our ability to care for these patients.“Genetic test
12、ing today starts at the earliest stages of life. Couples planning to have children can be screened prior to conception to see if they are carriers of genetic diseases; prenatal (产前) tests are offered during pregnancy, and states now screen newborns for as many as 29 conditions, the majority of them
13、genetic disorders. For Jana and Tom Monaco, of Woodbridge, Va., early testing has made an enormous difference in the lives of their children. Their journey began in 2001, when their seemingly healthy third child, 3-year-old Stephen, developed a life-threatening stomach virus that led to severe brain
14、 damage. His diagnosis: a rare but treatable disease called isovaleric acidemia (IVA). Unknowingly, Jana and her husband were carriers of the disease, and at the time, IVA was not included in newborn screening. The Monacos had no warning whatsoever.Not Take the TestingGenetic testing, exciting as it
15、 may seem, isnt always the answer. When Wendy Uhlmann, a genetic counselor at the University of Michigan, teaches medical students, she flashes two slides on a screen side by side. One says ignorance is bliss (福佑). The other: knowledge is power. Thats because the value of testing becomes especially
16、ambiguousand ethically complicatedwhen there is no way to prevent or treat disease, as in the case of early-onset Alzheimers, which often strikes before the age of 50, or Huntingtons.Today only about 5 percent of people who are at risk for Huntingtonswhich is caused by a single gene and leads to a p
17、rogressive loss of physical control and mental acuitytake the test. Many are worried that genetic testing will put their health insurance or job security at risk. While there have been few documented cases of discrimination, nobody can say for sure what will happen as more disease genes are discover
18、ed and more Americans sign on for predictive testing. States have a patchwork of regulations in place, but what needs to happen now, experts say, is for Congress to pass the Genetic Information Nondiscrimination Act, which would put a federal stamp of approval on keeping genetic information safe.Mor
19、eover, some people cant live with uncertainty. Stephanie Vogt knew Huntington ran in her familyher grandfather and his three brothers all died of complications of the diseaseand she wanted to find out where she stood. “As soon as I found out there was a test, I just had to do it,“ she says. In Augus
20、t 2000, after comprehensive genetic counseling, Stephanie, her sister, Victoria, and their mother, Gayle Smith, learned her results: positive. “It was like a scene Out of The Matrix, where everything freezes and starts again,“ says Stephanie, now 35 and single.Scientific revolutions must be tempered
21、 by reality. Genes arent the only factors involved in complex diseaseslifestyle and environmental influences, such as diet or smoking, are too. And predictions about new tests and treatments may not come to pass as fast as researchers hopethey may not come at all. Still, its hard not to get excited
22、about the future, especially when you consider the medical competition now underway.(分数:70.00)(1).Pauline Gross felt seared because she thought she would die of _.(分数:7.00)A.strokeB.cancerC.SARSD.AIDS(2).Genetic testing can be used to decide whether a patient has the inheritable gene mutation by pee
23、ring into their _.(分数:7.00)A.blood cellB.lung cellC.liver cellD.DNA(3).The major purpose of genetic testing in medication is to _.(分数:7.00)A.predict the death rate of inheritable diseaseB.predict a patients response to medicationC.find out the biological source and fix the problemD.guide safe and ap
24、propriate treatment(4).What have Christopher Ross experimental results revealed to us?(分数:7.00)A.Those inheritable diseases may be cured through genetic testing.B.Those inheritable diseases may be predicted through genetic testing.C.Those inheritable diseases may be prevented through genetic testing
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- 大学 1108 答案 解析 DOC
