GOST 32474-2013 Testing of chemicals of environmental hazard Partition Coefficient (n-octanol water) HPLC Method《环境危险化学品的试验 分配系数 (正辛醇 水) 高效液相色谱法》.pdf

《GOST 32474-2013 Testing of chemicals of environmental hazard Partition Coefficient (n-octanol water) HPLC Method《环境危险化学品的试验 分配系数 (正辛醇 水) 高效液相色谱法》.pdf》由会员分享，可在线阅读，更多相关《GOST 32474-2013 Testing of chemicals of environmental hazard Partition Coefficient (n-octanol water) HPLC Method《环境危险化学品的试验 分配系数 (正辛醇 水) 高效液相色谱法》.pdf（16页珍藏版）》请在麦多课文档分享上搜索。

1、 , ( )INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION(ISC) 32474 2013 , / (OECD Test No 117:2004, IDT) 2014 32474 2013 II, 1.0 92 . 1.2 2009 . , - . , , -, 1 - , , - ( )2 3 , (- 61 5 2013 .) : ( 3166) 004 97 ( 3166)004 97 AMBYKGMDRUTJUZ -4 22 2013 . 787- 32474 2013 - 1 2014 . 5 O

2、ECD Test No 117:2004 Partition Coef ient (n-o tano ater), P C Met o ( No 117 ( ), ). (en). (IDT)6 - , - . ( ) - . , , 2014 -, . 32474 2013 III , - , . OECD OECD Guideline For The Testing of Chemicals. Partition Coef cient (n-octanol/water), High Performance Liquid Chromatography (HPLC), - 13 2004 .

3、32474 2013 IV1 32474 2013 2014 08 011 - -/ . 2 :2.1 -/ (Kow): - , .2.2 : , , .3 3.1 - / (Kow) , - . - . Kow = - / - ; . , Kow .3.2 Kow - . . , Kow - . 3.3 logKow ( c 5)1) - 2. () Kow . Kow , , -1) . - , Kow. , -/ Testing of chemicals of environmental hazard.Partition Coef cient (n-octanol/water), HP

4、LC Method(1) 32474 2013 2 . . . 3.4 Kow , , , ., Kow - . , , - ( 3.8). 3.5 - , , ( , 8, 18) . 3.6 - , . - - , , . k, :00,rt tk t= tr ;t0 , . . , . , - . 3.7 / k, - k log Kow=a + blogk , b = . logKow .3.8 - logKow , , , logKow . , . , , , , - . ( ) , pKa pKa . - pKa . . logKow - , , , , . 3.9 - - . ,

5、 logKow . , , , logKow, - Kow . , 5 % .(2)(3) 32474 2013 3 logKow = (log ) ( ,%) (log )( ,%),% (owowiiiK i i K i %)= logKow ( , ), ( , ). , - .4 4.1 , , - . - .4.2 4.2.1 , . : Kow, , - , 0,1 log . : , . , R logk logKow 0,9.4.2.2 , - logKow 0,5 . , , .4.3 4.3.1 , - k Kow (. 4.8.3). - . , , logKow, lo

6、gKow , . ., Kow , Kow , - . . , , - . logKow, , - . , logKow ( , ) , . , - . 4.3.2 logKow - . - , , - . Kow 1. . - .( ) i (, ) i , % ( )o i ) ( i, %) (4) 32474 2013 4 1 CAS logKow pKa1 78-93-3 2- () 0,32 1122-54-9 4- 0,53 62-53-3 0,94 103-84-4 1,05 100-51-6 1,16 150-76-5 4- 1,3 10,267 122-59-8 1,4 3

7、,128 108-95-2 1,5 9,929 51-28-5 2,4- 1,5 3,9610 100-47-0 1,611 140-29-4 1,612 589-18-4 4- 1,613 98-86-2 1,714 88-75-5 2- 1,8 7,1715 121-92-6 3- 1,8 3,4716 106-47-8 4- 1,8 4,1517 98-95-3 1,918 104-54-1 () 1,919 65-85-0 1,9 4,1920 106-44-5 - 1,9 10,1721 140-10-3 () (E)-3- () 2,1 3,89 () 4,44 ()22 100-

8、66-3 2,123 93-58-3 2,124 71-43-2 2,125 99-04-7 3- 2,4 4,2726 106-48-9 4- 2,4 9,127 79-01-6 1,1,2- 2,428 1912-24-9 2-4- () 2,629 93-89-0 2,630 1194-65-6 2,6- 2,631 535-80-8 3- 2,7 3,8232 108-88-3 2,733 90-15-3 -1- 2,7 9,3434 608-27-5 2,3- 2,835 108-90-7 2,836 1746-13-0 2,937 108-86-1 3,038 100-41-4 3

9、,239 119-61-9 3,240 92-69-3 4- 3,2 9,5441 89-83-8 5-2-2- () 3,342 106-46-7 1,4- 3,443 122-39-4 3,4 0,7944 91-20-3 3,645 93-99-2 3,646 98-82-8 3,747 88-06-2 2,4,6- 3,7 648 92-52-4 4,049 120-51-4 4,050 88-85-7 2,4-6- 4,151 120-82-1 1,2,4- 4,2 32474 2013 5CAS logKow pKa52 143-07-7 4,2 5,353 101-84-8 4,254 85-01-8 4,555 104-51-8 n- 4,656 103-29-7 4,857 3558-69-8 2,6- 4,958 206-44-0 5,159 603-34-9 5,760 50-29-3 1,1,1-2,2-(-) () 6,54.4 , (. ), , ,