1、 , () INTERSTATE COUNCIL FOR STANDARDIZATION, METROLOGY AND CERTIFICATION (ISC) ISO 24444 2013 (SPF) (in vivo) (ISO 24444:2010, IDT) 2014 ISO 24444201 3 II , - 1.0 92 . 1.22009 . -, . , , , 1 - ( ) - ( ) - , 4 2 ( 360) 3 , (- 14 2013 . 44-2013) : ( 3166) 00497 ( 3166) 00497 AM KZ MD RU UZ - 4 ISO 24
2、444:2010 Cosmetics Sun Protection test methods In vivo determination of the sun protection factor (SPF) . - . (SPF) (in vivo). ISO/TC 217 (ISO). () (), , (3) (/3), , - . : D.2 D 10 n 8 10 - . (en). , - , - (IDT) 5 22 2013 . 2079- 1 2015 . ISO 24444201 3 III 6 , - . - () . , - , 2013 , - ISO 24444201
3、 3 IV 1 . 1 2 . 1 3 . 2 4 2 4.1 . 2 4.2 3 4.3 , 3 5 . 3 5.1 . 3 5.2 5 6 5 6.1 5 6.2 . 5 6.3 5 6.4 6 6.4.4 . 6 6.5 . 7 6.6 8 6.7 MED 8 7 . 9 7.1 (SPFi) 9 7.2 SPF 9 7.3 9 7.4 9 8 10 A () . 11 B () 13 C () SPF C.1 SPF 20 D () 26 E () , . 31 ISO 24444201 3 V , , (SPF), -. SPF , , - . , - . ISO/TR 26369
4、4. , , . . , SPF , , . ISO 24444 2013 1 (SPF) (in vivo) Cosmetics. Sun Protection test methods. Determination of the sun protection factor (SPF) on living organisms (in vivo) 2015 01 01 1 (SPF) - ( ) (in vivo). , , - , , . - , . 2 . 2.1 (ultraviolet radiation, UVR): 290 400 . 2.1.1 B (ultraviolet B,
5、 UVB): - 290 320 . 2.1.2 A (ultraviolet A, UVA): 320 400 . UVA II 320340 ; UVA I 340400 . 2.2 (erythema): , -. 2.3 (sunscreen products): , , , , - . 2.4 (minimal erythemal dose, MED): - (UVR), - , , - , 16 24 . 2.4.1 MEDu: MED . 2.4.2 MEDp: MED , . 2.5 (individual sun protection factor, SPFi): , (ME
6、Dp), (MEDu) : ISO 24444201 3 2 MED( ) MEDpSPFiMED( ) MEDu= = . SPFi (. 7.1). 2.6 (sun protection factor of a product, SPF): - SPFi, -. SPF (. 7.2). 2.7 , (test area): . 2.8 , (test site): , - MED . 2.9 , (exposure sub-sites): . 2.10 (individual typology angle, ITA): , - . 3 SPF , - ( ), - , , , , .
7、. - ; ( ) - . - SPF, . - . 16 24 . - . (MED) (MEDu) MED, - (. . MED , -, MEDp) . (SPFi) - MED , , MED - , . . MEDp/MEDu. (SPF) - SPFi . 4 4.1 4.1.1 , , . - A. 4.1.2 , SPF, - I, II III 7, ITA 28, - (. A E), , -. SPF , . ISO 24444201 3 3 ( ), - , -, , (. - A). 4.1.3 , 70 , - SPF. 4.1.4 - , , , , , , . 4.1.5 8 , - , . ( -), , . 4.2 SPFi 10, - SPFi 20. , 10 20 , SPF. , 10 25 (. . 20 - ). SPF 6.7.4 -. 95 %- (95 % CI) SPF. 10 . 95 % CI - SPF 10 17 % SPF. , 10, - 95 % CI ( 20 25 ). 20 - 25 , . - , -
