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    BS ISO CIE 28077-2016 Photocarcinogenesis action spectrum (non-melanoma skin cancers)《光致癌作用光谱(非黑素瘤皮肤癌)》.pdf

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    BS ISO CIE 28077-2016 Photocarcinogenesis action spectrum (non-melanoma skin cancers)《光致癌作用光谱(非黑素瘤皮肤癌)》.pdf

    1、BS ISO/CIE 28077:2016 Photocarcinogenesis action spectrum (non-melanoma skin cancers) BSI Standards Publication WB11885_BSI_StandardCovs_2013_AW.indd 1 15/05/2013 15:06BS ISO/CIE 28077:2016 BRITISH STANDARD National foreword This British Standard is the UK implementation of ISO/CIE 28077:2016. It su

    2、persedes BS ISO 28077:2006 which is withdrawn. The UK participation in its preparation was entrusted to Technical Committee EL/1, Light and lighting applications. A list of organizations represented on this committee can be obtained on request to its secretary. This publication does not purport to i

    3、nclude all the necessary provisions of a contract. Users are responsible for its correct application. The British Standards Institution 2016. Published by BSI Standards Limited 2016 ISBN 978 0 580 91606 9 ICS 13.280; 17.180.20 Compliance with a British Standard cannot confer immunity from legal obli

    4、gations. This British Standard was published under the authority of the Standards Policy and Strategy Committee on 31 October 2016. Amendments/corrigenda issued since publication Date T e x t a f f e c t e dBS ISO/CIE 28077:2016 Photocarcinogenesis action spectrum (non-melanoma skin cancers) Spectre

    5、 daction de la photocarcinogense (cancers de la peau hors mlanome) INTERNATIONAL STANDARD ISO/CIE 28077 Reference number ISO/CIE 28077:2016(E) Second edition 2016-10-01 ISO/CIE 2016 BS ISO/CIE 28077:2016ii ISO/CIE 2016 All rights reserved COPYRIGHT PROTECTED DOCUMENT ISO/CIE 2016, Published in Switz

    6、erland All rights reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on the internet or an intranet, without prior written permission. Permission can be re

    7、quested from either ISO at the address below or ISOs member body in the country of the requester. ISO copyright office CIE Central Bureau Ch. de Blandonnet 8 CP 401 Babenbergerstrae 9/9A CH-1214 Vernier, Geneva, Switzerland A-1010 Vienna, Austria Tel. +41 22 749 01 11 Tel. +43 1 714 3187 Fax +41 22

    8、749 09 47 copyrightiso.org ciecbcie.co.at www.iso.org www.cie.co.at ISO/CIE 28077:2016(E)BS ISO/CIE 28077:2016ISO/CIE 28077:2016(E)Foreword iv Introduction v 1 Scope . 1 2 Normative references 1 3 T erms, definitions, s ymbols and abbr e viations . 1 3.1 Terms and definitions . 1 3.2 Symbols and abb

    9、reviations 1 4 The action spectrum for photocarcinogenesis of non-melanoma skin cancers .1 5 T abulat ed and gr aphic v alues . 2 Bibliogr aph y 7 ISO/CIE 2016 All rights reserved iii Contents PageBS ISO/CIE 28077:2016ISO/CIE 28077:2016(E) Foreword ISO (the International Organization for Standardiza

    10、tion) is a worldwide federation of national standards bodies (ISO member bodies). The work of preparing International Standards is normally carried out through ISO technical committees. Each member body interested in a subject for which a technical committee has been established has the right to be

    11、represented on that committee. International organizations, governmental and non-governmental, in liaison with ISO, also take part in the work. ISO collaborates closely with the International Electrotechnical Commission (IEC) on all matters of electrotechnical standardization. The procedures used to

    12、 develop this document and those intended for its further maintenance are described in the ISO/IEC Directives, Part 1. In particular the different approval criteria needed for the different types of ISO documents should be noted. This document was drafted in accordance with the editorial rules of th

    13、e ISO/IEC Directives, Part 2 (see www.iso.org/directives). Attention is drawn to the possibility that some of the elements of this document may be the subject of patent rights. ISO shall not be held responsible for identifying any or all such patent rights. Details of any patent rights identified du

    14、ring the development of the document will be in the Introduction and/or on the ISO list of patent declarations received (see www.iso.org/patents). Any trade name used in this document is information given for the convenience of users and does not constitute an endorsement. For an explanation on the

    15、meaning of ISO specific terms and expressions related to conformit y assessment, as well as information about ISOs adherence to the World Trade Organization (WTO) principles in the Technical Barriers to Trade (TBT) see the following URL: www.iso.org/iso/foreword.html. ISO/CIE 28077 was prepared by C

    16、IE Technical Committee 6-32, Action Spectrum for Photocarcinogenesis, as CIE S 019. The committee responsible for this document is ISO/TC 274, Light and lighting. This second edition cancels and replaces the first edition (ISO 28077:2006), of which it constitutes a minor revision.iv ISO/CIE 2016 All

    17、 rights reservedBS ISO/CIE 28077:2016ISO/CIE 28077:2016(E) Introduction Solar ultraviolet radiation (UVR) is recognized as a major cause of non-melanoma skin cancer in human beings. Skin cancer occurs most frequently in the most heavily exposed areas and correlates with degree of outdoor exposure. D

    18、escribing the relationship of exposure (dose) to risk (skin cancer) requires the availability of a biological hazard function or action spectrum for photocarcinogenesis. This document proposes the adoption of an action spectrum (weighting function) derived from experimental laboratory data and modif

    19、ied to estimate the non-melanoma tumour response in human skin. The experimental data are sufficient for estimating effectiveness down to about 250 nm, but experimental data are not sufficient for specifying effectiveness above 400 nm. ISO/CIE 2016 All rights reserved vBS ISO/CIE 28077:2016BS ISO/CI

    20、E 28077:2016Photocarcinogenesis action spectrum (non-melanoma skin cancers) 1 Scope This document specifies the action spectrum for photocarcinogenesis of non-melanoma skin cancers. 2 Normative references There are no normative references in this document. 3 T erms, d efinitions , s ymbols and abbr

    21、e viations For the purposes of this document, the terms and definitions given in CIE S 017 /E:2011 and the following terms and definitions, symbols and abbreviations apply. ISO and IEC maintain terminological databases for use in standardization at the following addresses: IEC Electropedia: availabl

    22、e at http:/ /www.electropedia.org/ ISO Online browsing platform: available at http:/ /www.iso.org/obp 3.1 T erms and definiti ons 3.1.1 ultraviolet radiation UVR radiation for which the wavelengths are shorter than those for visible radiation Note 1 to entry: The range between 100 nm and 400 nm is c

    23、ommonly subdivided into: UV-A: 315 nm to 400 nm; UV-B: 280 nm to 315 nm; UV-C: 100 nm to 280 nm. SOURCE: CIE S 017 /E:2011, Term 17-1367, modified Notes 2 and 3 have been omitted. 3.2 S ymbols and abbr e viations SCUP Skin Cancer Utrecht-Philadelphia (an action spectrum proposed in Reference 1) SCUP

    24、-m designates the original SCUP action spectrum, based entirely on mouse data SCUP-h designates a proposed action spectrum estimated by correcting for differences in UV transmissions between human and murine epidermis UV-A1 wavelength range from 340 nm to 400 nm UV-A2 wavelength range from 315 nm to

    25、 340 nm 4 The action spectrum for photocarcinogenesis of non-melanoma skin cancers The effectiveness of ultraviolet radiation in causing photocarcinogenesis of non-melanoma skin cancers has been studied for many years 1-16 . The action spectrum defined in this document was first published by the CIE

    26、 as the product of research by CIE Technical Committee 6-32, as CIE 138/2. 16The document stated the following recognized limitations to this action spectrum: INTERNATIONAL ST ANDARD ISO/CIE 28077:2016(E) ISO/CIE 2016 All rights reserved 1BS ISO/CIE 28077:2016ISO/CIE 28077:2016(E) “The UV-A1 part (3

    27、40 nm400 nm) of the SCUP action spectra has large margins of uncertainty (from 10 %20 % at 340 nm to an order of magnitude at 390 nm); the minimum at 350 nm and especially the secondary maximum at 380 nm are not well defined. Recent biochemical data do, however, indicate that action spectra for some

    28、 types of DNA damage from reactive oxygen species, such as released by UV-A, show a minimum around 350 nm. Exploiting this as yet ill-defined fine structure in the UV-A1 region of the SCUP-h action spectrum (e.g. for optimizing commercial tanning lamps) would be unjustified. Because the Committee re

    29、port should provide a standard for risk assessment in regulatory applications, its recommendation eliminates the uncertainty associated with the fine structure of the SCUP-h action spectrum. Committee consensus involved flattening the plateau at the 340 nm level. Mathematically, this results in the

    30、least available deterioration of the curve fit to the actual experimental data (the Chi- square of the fit goes up from 13,7 to 18,2 with 7 degrees of freedom).” 16 NOTE An action spectrum based on the Utrecht-Philadelphia collaboration bears the acronym “SCUP” (for Skin Cancer Utrecht Philadelphia)

    31、. “SCUP-m” is the best fit to the mouse data, using a computer polynomial program. Based on SCUP-m, a SCUP-h action spectrum (“-h” for human) was estimated by correcting for differences in UV transmissions between human and murine epidermis. 17 The action spectrum for photocarcinogenesis is based pr

    32、incipally on experimental data from mice; comparable data are obviously not available from humans. The limits of this extrapolation are yet to be determined. Based on all these considerations, a standard action spectrum for photocarcinogenesis is provided in Table 1 and shown in Figure 1. 5 T abulat

    33、 ed and gr aphic v alues T a b l e 1 A c t i o n s p e c t r u m f o r p h o t o c a r c i n o g e n e s i s ( n o n - m e l a n o m a s k i n c a n c e r ) Wavelength / nm Effectiveness (decimal) Effectiveness (exponential) 250 0,010 900 1,090 00E-02 251 0,011 139 1,113 90E-02 252 0,011 383 1,138 3

    34、0E-02 253 0,011 633 1,163 30E-02 254 0,011 888 1,188 80E-02 255 0,012 158 1,215 80E-02 256 0,012 435 1,243 50E-02 257 0,012 718 1,271 80E-02 258 0,013 007 1,300 70E-02 259 0,013 303 1,330 30E-02 260 0,013 605 1,360 50E-02 261 0,013 915 1,391 50E-02 262 0,014 231 1,423 10E-02 263 0,014 555 1,455 50E-

    35、02 264 0,014 886 1,488 60E-02 265 0,015 225 1,522 50E-02 266 0,015 571 1,557 10E-02 267 0,015 925 1,592 50E-02 268 0,016 287 1,628 70E-02 269 0,016 658 1,665 80E-02 270 0,017 037 1,703 70E-02 271 0,017 424 1,742 40E-022 ISO/CIE 2016 All rights reservedBS ISO/CIE 28077:2016ISO/CIE 28077:2016(E) Wavel

    36、ength / nm Effectiveness (decimal) Effectiveness (exponential) 272 0,017 821 1,782 10E-02 273 0,018 226 1,822 60E-02 274 0,018 641 1,864 10E-02 275 0,019 065 1,906 50E-02 276 0,019 498 1,949 80E-02 277 0,019 942 1,994 20E-02 278 0,020 395 2,039 50E-02 279 0,020 859 2,085 90E-02 280 0,021 334 2,133 4

    37、0E-02 281 0,025 368 2,536 80E-02 282 0,030 166 3,016 60E-02 283 0,035 871 3,587 10E-02 284 0,057 388 5,738 80E-02 285 0,088 044 8,804 40E-02 286 0,129 670 1,296 70E-01 287 0,183 618 1,836 18E-01 288 0,250 586 2,505 86E-01 289 0,330 048 3,300 48E-01 290 0,420 338 4,203 38E-01 291 0,514 138 5,141 38E-

    38、01 292 0,609 954 6,099 54E-01 293 0,703 140 7,031 40E-01 294 0,788 659 7,886 59E-01 295 0,861 948 8,619 48E-01 296 0,919 650 9,196 50E-01 297 0,958 965 9,589 65E-01 298 0,988 917 9,889 17E-01 299 1,000 000 1,000 00E+00 300 0,991 996 9,919 96E-01 301 0,967 660 9,676 60E-01 302 0,929 095 9,290 95E-01

    39、303 0,798 410 7,984 10E-01 304 0,677 339 6,773 39E-01 305 0,567 466 5,674 66E-01 306 0,470 257 4,702 57E-01 307 0,385 911 3,859 11E-01 308 0,313 889 3,138 89E-01 309 0,253 391 2,533 91E-01 310 0,203 182 2,031 82E-01 311 0,162 032 1,620 32E-01 312 0,128 671 1,286 71E-01 313 0,101 794 1,017 94E-01 314

    40、 0,079 247 7,924 70E-02T a b l e 1 (continued) ISO/CIE 2016 All rights reserved 3BS ISO/CIE 28077:2016ISO/CIE 28077:2016(E) Wavelength / nm Effectiveness (decimal) Effectiveness (exponential) 315 0,061 659 6,165 90E-02 316 0,047 902 4,790 20E-02 317 0,037 223 3,722 30E-02 318 0,028 934 2,893 40E-02

    41、319 0,022 529 2,252 90E-02 320 0,017 584 1,758 40E-02 321 0,013 758 1,375 80E-02 322 0,010 804 1,080 40E-02 323 0,008 525 8,525 00E-03 324 0,006 756 6,756 00E-03 325 0,005 385 5,385 00E-03 326 0,004 316 4,316 00E-03 327 0,003 483 3,483 00E-03 328 0,002 830 2,830 00E-03 329 0,002 316 2,316 00E-03 330

    42、 0,001 911 1,911 00E-03 331 0,001 590 1,590 00E-03 332 0,001 333 1,333 00E-03 333 0,001 129 1,129 00E-03 334 0,000 964 9,640 00E-04 335 0,000 810 8,100 00E-04 336 0,000 688 6,880 00E-04 337 0,000 589 5,890 00E-04 338 0,000 510 5,100 00E-04 339 0,000 446 4,460 00E-04 340 0,000 394 3,940 00E-04 341 0,

    43、000 394 3,940 00E-04 342 0,000 394 3,940 00E-04 343 0,000 394 3,940 00E-04 344 0,000 394 3,940 00E-04 345 0,000 394 3,940 00E-04 346 0,000 394 3,940 00E-04 347 0,000 394 3,940 00E-04 348 0,000 394 3,940 00E-04 349 0,000 394 3,940 00E-04 350 0,000 394 3,940 00E-04 351 0,000 394 3,940 00E-04 352 0,000

    44、 394 3,940 00E-04 353 0,000 394 3,940 00E-04 354 0,000 394 3,940 00E-04 355 0,000 394 3,940 00E-04 356 0,000 394 3,940 00E-04 357 0,000 394 3,940 00E-04T a b l e 1 (continued) 4 ISO/CIE 2016 All rights reservedBS ISO/CIE 28077:2016ISO/CIE 28077:2016(E) Wavelength / nm Effectiveness (decimal) Effecti

    45、veness (exponential) 358 0,000 394 3,940 00E-04 359 0,000 394 3,940 00E-04 360 0,000 394 3,940 00E-04 361 0,000 394 3,940 00E-04 362 0,000 394 3,940 00E-04 363 0,000 394 3,940 00E-04 364 0,000 394 3,940 00E-04 365 0,000 394 3,940 00E-04 366 0,000 394 3,940 00E-04 367 0,000 394 3,940 00E-04 368 0,000

    46、 394 3,940 00E-04 369 0,000 394 3,940 00E-04 370 0,000 394 3,940 00E-04 371 0,000 394 3,940 00E-04 372 0,000 394 3,940 00E-04 373 0,000 394 3,940 00E-04 374 0,000 394 3,940 00E-04 375 0,000 394 3,940 00E-04 376 0,000 394 3,940 00E-04 377 0,000 394 3,940 00E-04 378 0,000 394 3,940 00E-04 379 0,000 39

    47、4 3,940 00E-04 380 0,000 394 3,940 00E-04 381 0,000 394 3,940 00E-04 382 0,000 394 3,940 00E-04 383 0,000 394 3,940 00E-04 384 0,000 394 3,940 00E-04 385 0,000 394 3,940 00E-04 386 0,000 394 3,940 00E-04 387 0,000 394 3,940 00E-04 388 0,000 394 3,940 00E-04 389 0,000 394 3,940 00E-04 390 0,000 394 3

    48、,940 00E-04 391 0,000 394 3,940 00E-04 392 0,000 394 3,940 00E-04 393 0,000 394 3,940 00E-04 394 0,000 394 3,940 00E-04 395 0,000 394 3,940 00E-04 396 0,000 394 3,940 00E-04 397 0,000 394 3,940 00E-04 398 0,000 394 3,940 00E-04 399 0,000 394 3,940 00E-04 400 0,000 394 3,940 00E-04T a b l e 1 (contin

    49、ued) ISO/CIE 2016 All rights reserved 5BS ISO/CIE 28077:2016ISO/CIE 28077:2016(E) Key X wavelength (nm) Y relative effectiveness F i g u r e 1 A c t i o n s p e c t r u m f o r p h o t o c a r c i n o g e n e s i s : n o n - m e l a n o m a s k i n c a n c e r6 ISO/CIE 2016 All rights reservedBS ISO/CIE 28077:2016ISO/CIE 28077:2016(E) Bibliogr aph y 1 De Gruijl F . R. , & V an Der Leun J.C. Estimate of the wavelength dependency of ultraviolet carcinogenesis in humans a


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