1、 ISO 2016 Health informatics Identification of medicinal products Implementation guidelines for data elements and structures for the unique identification and exchange of regulated information on substances Informatique de sant Identification des mdicaments Lignes directrices pour la mise en oeuvre
2、des lments de donnes et structures pour lidentification unique et lchange dinformations rglementes sur les substances TECHNICAL SPECIFICATION ISO/TS 19844 Reference number ISO/TS 19844:2016(E) Second edition 2016-12-15ISO/TS 19844:2016(E)ii ISO 2016 All rights reserved COPYRIGHT PROTECTED DOCUMENT I
3、SO 2016, Published in Switzerland All rights reserved. Unless otherwise specified, no part of this publication may be reproduced or utilized otherwise in any form or by any means, electronic or mechanical, including photocopying, or posting on the internet or an intranet, without prior written permi
4、ssion. Permission can be requested from either ISO at the address below or ISOs member body in the country of the requester. ISO copyright office Ch. de Blandonnet 8 CP 401 CH-1214 Vernier, Geneva, Switzerland Tel. +41 22 749 01 11 Fax +41 22 749 09 47 copyrightiso.org www.iso.orgISO/TS 19844:2016 I
5、SO 2016 All rights reserved iii Contents 1 Scope 1 2 Normative references 2 3 General background and history .2 4 Substance (Mandatory) .3 4.1 General 3 4.2 Defining substances 5 4.2.1 Substance type (Mandatory) .7 4.2.2 Substance ID (Mandatory) . 10 4.3 Substance names (Mandatory) 11 4.3.1 Substanc
6、e name . 12 4.3.2 Substance name type . 13 4.3.3 Language 14 4.3.4 Official name (Conditional. 14 4.4 Reference source (Conditional) . 17 4.4.1 Public domain 17 4.4.2 Reference source type . 18 4.4.3 Reference source class 18 4.4.4 Reference source ID . 19 4.4.5 Reference source citation 19 4.5 Refe
7、rence source document (Conditional) . 19 4.5.1 Public domain 19 4.5.2 Reference source document . 20 4.5.3 Reference source document type . 20 4.5.4 Reference source document ID 21 4.5.5 Reference source document classification 21 4.5.6 Reference source document URL 21 4.6 Substance code (Conditiona
8、l) 21 4.6.1 Code . 22 4.6.2 Code system 22 4.6.3 Code system ID . 23 4.6.4 Code system status . 23 4.6.5 Code change date 24 4.6.6 Comment 24 4.6.7 Reference source 24 4.7 Reference information (Conditional) 24 4.7.1 Comment 25 4.7.2 Substance classification (Conditional) 25 4.7.3 Substance relation
9、ship (Conditional) . 28 4.7.4 Target (Conditional) 30 4.7.5 Gene (Conditional) . 33 4.7.6 Gene element (Conditional) 35 4.8 Structure 36 4.8.1 Structural Representation (Conditional) . 36 4.8.2 Stereochemistry 42 4.8.3 Optical activity . 43 ISO/TS 19844:2016 iv ISO 2016 All rights reserved 4.8.4 Mol
10、ecular Formula 44 4.8.5 Molecular Formula by Moiety 44 4.8.6 Molecular weight (Mandatory) . 44 4.8.7 Isotope (Conditional) 44 4.9 Amount (Conditional) . 46 4.9.1 Average 46 4.9.2 Low limit 47 4.9.3 High limit . 47 4.9.4 Unit 47 4.9.5 Non-numeric Value 48 4.9.6 Reference Source (Conditional) 48 4.9.7
11、 Reference source document (Conditional) . 48 4.10 Source material (Conditional) . 48 4.10.1 Source material class 49 4.10.2 Source material type . 50 4.10.3 Source material state 50 4.10.4 Organism ID 50 4.10.5 Organism name . 51 4.10.6 Parent substance ID 51 4.10.7 Parent substance name 51 4.10.8
12、Development stage 52 4.10.9 Part Description (CONDITIONAL) 52 4.10.10 Fraction (Conditional) 54 4.10.11 Organism (Conditional) 57 4.11 Modification (Conditional) . 64 4.11.1 Modification type . 66 4.11.2 Residue modified . 66 4.11.3 Residue sites 66 4.11.4 Structural modification (Conditional) 67 4.
13、11.5 Agent modification (Conditional) 69 4.11.6 Physical Modification (Conditional) 70 4.12 Property (Conditional) . 72 4.12.1 Property type . 72 4.12.2 Property name 73 4.12.3 Property parameters 73 4.12.4 Substance ID . 73 4.12.5 Substance name 74 4.12.6 Amount type (Mandatory) 74 4.13 Version (Ma
14、ndatory) 74 4.13.1 Version number 74 4.13.2 Effective date . 75 4.13.3 Change made 75 5 Substance definitions . 75 5.1 Chemical substance . 75 5.1.1 Comment . 76 5.1.2 Structure 77 5.1.3 Stoichiometric/Non-stoichiometric chemicals . 77 5.1.4 Stoichiometric chemicals 78 5.1.5 Non-stoichiometric chemi
15、cals (Conditional) . 81 5.1.6 Substance Name (Mandatory) . 83 5.1.7 Substance Code (Conditional) 83 5.1.8 Version (Mandatory) 83 ISO/TS 19844:2016 ISO 2016 All rights reserved v 5.1.9 Reference information 83 5.1.10 Reference source (Conditional) . 83 5.1.11 Reference source document (Conditional) .
16、 83 5.2 Proteins/peptides 83 5.2.1 Microheterogeneity . 84 5.2.2 Sequence type 86 5.2.3 Number of subunits 86 5.2.4 Disulfide linkage . 86 5.2.5 Comment 87 5.2.6 Protein subunit (Mandatory) . 87 5.2.7 Molecular weight (Conditional) 90 5.2.8 Glycosylation (Conditional) 91 5.2.9 Property (Conditional)
17、 . 92 5.2.10 Structure (Mandatory) 93 5.2.11 Substance name (Mandatory) 93 5.2.12 Modification (Conditional) 93 5.2.13 Substance code (Conditional) 93 5.2.14 Source material (Conditional) . 93 5.2.15 Version (Mandatory) . 93 5.2.16 Reference information (Conditional) 93 5.2.17 Reference source (Cond
18、itional) . 93 5.2.18 Reference source document (Conditional) . 93 5.3 Nucleic acids . 93 5.3.1 Structure (Conditional) 94 5.3.2 Sequence type 95 5.3.3 Number of subunits 95 5.3.4 Area of hybridisation. 96 5.3.5 Comment 96 5.3.6 Nucleic acid subunit (Mandatory) 96 5.3.7 Modification (Conditional) . 1
19、00 5.3.8 Property (Conditional) 100 5.3.9 Molecular weight (Conditional) . 101 5.3.10 Substance Name (Mandatory) . 101 5.3.11 Substance Code (Conditional) . 101 5.3.12 Version (Mandatory) 101 5.3.13 Reference information (Conditional) . 101 5.3.14 Reference source (Conditional) 101 5.3.15 Reference
20、source document (Conditional) 101 5.4 Polymers . 101 5.4.1 Polymer class 103 5.4.2 Polymer geometry . 103 5.4.3 Copolymer sequence type . 103 5.4.4 Comment . 103 5.4.5 Substance name (Mandatory) . 103 5.4.6 Structure (Mandatory) . 104 5.4.7 Monomer description (Conditional) . 104 5.4.8 Structural re
21、peat (Conditional) 105 5.4.9 Molecular weight (Mandatory) . 108 5.4.10 Property (Conditional) 108 5.4.11 Substance code (Conditional) . 108 5.4.12 Version (Mandatory) 108 5.4.13 Reference information (Conditional) . 108 ISO/TS 19844:2016 vi ISO 2016 All rights reserved 5.4.14 Modification (Condition
22、al) . 108 5.4.15 Source material (Conditional) . 109 5.4.16 Reference source (Conditional) 109 5.4.17 Reference source document (Conditional) . 109 5.5 Structurally diverse substances 109 5.5.1 Comment . 110 5.5.2 Substance name (Mandatory) 110 5.5.3 Structure (Mandatory) . 110 5.5.4 Property (Condi
23、tional) . 110 5.5.5 Molecular weight 111 5.5.6 Glycosylation (Conditional) 111 5.5.7 Modification (Conditional) . 111 5.5.8 Source material (Conditional) . 111 5.5.9 Substance code (Conditional) 111 5.5.10 Reference information (Conditional) . 111 5.5.11 Version (Mandatory) 111 5.5.12 Reference sour
24、ce (Conditional) 111 5.5.13 Reference source document (Conditional) . 111 5.5.14 Herbals and substances used in the preparation of plant-based allergenic extracts . 111 5.5.15 Vaccines . 114 5.5.16 Plasma-derived substance for human blood products and polyclonal antibodies 114 5.5.17 Allergens 114 5
25、.5.18 Advance Therapies and Advanced Vaccines (Genes, Modified Viruses, Cells and Tissues as Substances) . 115 5.5.19 Minerals . 115 5.6 Mixture substance 116 5.6.1 Mixture type . 116 5.6.2 Mixture constituent (Mandatory) 116 5.6.3 Modification (Conditional) . 117 5.6.4 Source material (Conditional)
26、 . 117 5.6.5 Substance name (Mandatory) 117 5.6.6 Substance code (Conditional) 117 5.6.7 Reference information (Conditional) . 118 5.6.8 Version (Mandatory) 118 6 Specified substance (Optional) . 118 6.1 Specified Substance Group 1 (repeat as necessary) 118 6.1.1 Specified substance Group 1 ID . 119
27、 6.1.2 Specified substance Group1 Name . 120 6.1.3 Substance Name (Mandatory) . 120 6.1.4 Substance Code (Conditional) 120 6.1.5 Version (Mandatory) 120 6.1.6 Reference source (Conditional) 120 6.1.7 Reference source document (Conditional) . 120 6.1.8 Property (Conditional) . 120 6.1.9 Fraction (Con
28、ditional) 121 6.1.10 Modification (Conditional) . 125 6.1.11 Reference Information (Conditional) . 125 6.1.12 Constituent (Mandatory) . 125 6.1.13 Physical form (Conditional) . 127 6.1.14 Specified substance particulars 128 6.2 Specified substance Group 2 133 6.2.1 Specified Substance Group2 ID . 13
29、5 ISO/TS 19844:2016 ISO 2016 All rights reserved vii 6.2.2 Specified Substance Group2 Name 136 6.2.3 Parent Substance ID 136 6.2.4 Reference source (Conditional) 136 6.2.5 Reference source document (Conditional) 136 6.2.6 Manufacturing (Mandatory) 136 6.3 Specified Substance Group 2 for Herbal prepa
30、rations . 142 6.3.1 Specified Substance Group2 ID . 142 6.3.2 Specified substance Group2 Name 142 6.3.3 Parent Substance ID 142 6.3.4 Manufacturing . 143 6.3.5 Version. 144 6.4 Specified Substance Group 3 . 144 6.4.1 Specified Substance Group 3 ID 145 6.4.2 Specified Substance Group3 Name 145 6.4.3
31、Parent Substance ID 145 6.4.4 Grade (Mandatory) 145 6.4.5 Version (Mandatory) 146 6.4.6 Reference source (Conditional) 146 6.4.7 Reference source document (Conditional) 147 6.4.8 Substance name (Mandatory) . 147 6.4.9 Substance code (Conditional) . 147 6.4.10 Version (Mandatory) 147 7 Description of
32、 the information modelling principles and practices . 147 Annex A (normative) Choosing a Substance ID 148 Annex B (normative) Chemical substance . 150 Annex C (normative) Protein substance . 270 Annex D (normative) Nucleic acid substance . 329 Annex E (normative) Structurally Diverse Substance Herba
33、l Substance/Herbal Specified Substance 348 Annex F (normative) Structurally Diverse Substance, Homeopathic substance . 466 Annex G (normative) Structurally Diverse Substance Plasma-derived substances 509 Annex H (normative) Polymer Substance 581 viii ISO 2016 All rights reserved ISO/TS 19844:2016 Fo
34、reword ISO (the International Organization for Standardization) is a worldwide federation of national standards bodies (ISO member bodies). The work of preparing International Standards is normally carried out through ISO technical committees. Each member body interested in a subject for which a tec
35、hnical committee has been established has the right to be represented on that committee. International organizations, governmental and non-governmental, in liaison with ISO, also take part in the work. ISO collaborates closely with the International Electrotechnical Commission (IEC) on all matters o
36、f electrotechnical standardization. The procedures used to develop this document and those intended for its further maintenance are described in the ISO/IEC Directives, Part 1. In particular, the different approval criteria needed for the different types of ISO documents should be noted. This docume
37、nt was drafted in accordance with the editorial rules of the ISO/IEC Directives, Part 2 (see www.iso.org/directives). Attention is drawn to the possibility that some of the elements of this document may be the subject of patent rights. ISO shall not be held responsible for identifying any or all suc
38、h patent rights. Details of any patent rights identified during the development of the document will be in the Introduction and/or on the ISO list of patent declarations received (see www.iso.org/patents). Any trade name used in this document is information given for the convenience of users and doe
39、s not constitute an endorsement. For an explanation on the meaning of ISO specific terms and expressions related to conformity assessment, as well as information about ISOs adherence to the WTO principles in the Technical Barriers to Trade (TBT) see the following URL: Foreword - Supplementary inform
40、ation The committee responsible for this document is ISO/TC 215, Health informatics. This second edition cancels and replaces the first edition (ISO/TS 19844:2015), which has been technically revised.ISO/TS 19844:2016 ISO 2016 All rights reserved ix Introduction This document provides guidelines for
41、 implementing ISO 11238. This document is developed in response to a worldwide demand for guidance on the implementation of internationally harmonised specifications for medicinal products. It is one of a group of four implementation guides for a total of five ISO standards which together provide th
42、e basis for the unique identification of medicinal products. The other standards in this group are: - ISO 11615, Health informatics Identification of medicinal products Data elements and structures for the unique identification and exchange of regulated medicinal product information - ISO 11616, Hea
43、lth informatics Identification of medicinal products Data elements and structures for the unique identification and exchange of regulated pharmaceutical product information - ISO 11239, Health informatics Identification of medicinal products Data elements and structures for the unique identification
44、 and exchange of regulated information on pharmaceutical dose forms, units of presentation, routes of administration and packaging - ISO 11240, Health informatics Identification of medicinal products Data elements and structures for the unique identification and exchange of units of measurement The
45、standards for the Identification of Medicinal Products (IDMP) support the activities of medicines regulatory agencies worldwide by jurisdiction. These include a variety of regulatory activities related to development, registration and life cycle management of medicinal products as well as pharmacovi
46、gilance and risk management. The business objective of this implementation guide is to provide a means for exchanging regulatory substance information. To meet the primary objectives of the regulation of medicines and pharmacovigilance, it is necessary to exchange medicinal product information in a
47、robust and reliable manner. For the purposes of this document, all conditions (e.g. mandatory, conditional, optional) correspond to the necessary requirements to uniquely and unambiguously identify a substance. Implementation of the ISO IDMP standards may dictate that mandatory elements for identifi
48、cation be tagged as conditional or optional, based on regional requirements. If a subclause is identified as optional but is implemented in a specific region, conformance described within that subclause is applicable. The scope of this document is to identify the scientifically necessary elements fo
49、r the unique identification of Substances/Specified Substances. ISO/TS 19844 :2016 ISO 2015 All rights reserved 1 Health informatics Identification of medicinal products Implementation guidelines for data elements and structures for the unique identification and exchange of regulated information on substances 1 Scope This document is used in the implementation of ISO 11238. This document defines substances based on their scientific identity (i.e. what they are) rather than on their use or method of product
